Biphenyl derivatives as nhe-3 inhibitors

C - Chemistry – Metallurgy – 07 – C

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C07C 257/18 (2006.01) A61K 31/155 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) A61P 13/12 (2006.01) A61P 25/02 (2006.01) C07C 279/22 (2006.01)

Patent

CA 2387529

The invention relates to compounds of the formula (I), wherein X, R1, R2, R3, R4 and R5 have the meaning indicated in claim 1. The inventive compounds represent inhibitors of the subtype 3 sodium/proton exchanger (NHE-3).

La présente invention concerne des composés de formule (I) dans laquelle X, R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ ont les significations indiquées dans la revendication 1. Ces composés sont des inhibiteurs de l'échangeur à sodium et à protons de type 3 (NHE-3).

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