C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 65/17 (2006.01) A61K 31/19 (2006.01) A61K 31/235 (2006.01) A61P 17/00 (2006.01) A61Q 5/00 (2006.01) A61Q 19/00 (2006.01) C07C 65/26 (2006.01) C07C 69/94 (2006.01)
Patent
CA 2268799
The invention concerns compounds of formula (I) in which: Ar represents an aromatic radical or a heteroaromatic radical optionally substituted in particular by an alkyl or a carboxylic group; R2 and R3, represent in particular H, alkyl, or R2 and R3, together form a cycle with 5 or 6 chains; R4 and R5 represent in particular H or halogen; R6 represents in particular H or lower alkyl, and the salts of the compounds of formula (I). Said compounds can be used in particular for treating dermatological diseases related to keratinization disorder, and to fight against skin ageing.
Composés de formule (I), dans laquelle Ar représente un radical aromatique ou un radical hétéroaromatique éventuellement substitué notamment par un alkyle ou un groupe carboxylique, R2 et R3, représentent notamment H, alkyle, ou R2 et R3, pris ensemble forment un cycle à 5 ou 6 chaînons, R4 et R5 représentent notamment H ou halogène, R6 représente notamment H ou alkyle inférieur, et les sels des composés de formule (I). Ces composés sont utilisables notamment dans le traitement des affections dermatologiques liées à un désordre de la kératinisation, et pour lutter contre le vieillissement de la peau.
Bernardon Jean-Michel
Nedoncelle Philippe
Galderma Research & Development
Robic
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