Biphenyl derivatives, the preparation thereof and their use...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 211/58 (2006.01) A61K 31/4468 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2379841

The present invention relates to biphenyl derivatives of general formula (see formula I) wherein R a to R g and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.

L'invention concerne des dérivés de biphényle de formule générale (I) dans laquelle Ra à Rg et n sont définis dans la revendication 1. L'invention concerne également leurs isomères et leurs sels, notamment leurs sels physiologiquement tolérables. Ces composés constituent de précieux inhibiteurs de la protéine de transfert microsomale des triglycérides (MTP). L'invention concerne en outre des médicaments contenant ces composés, ainsi que l'utilisation et la production de ces derniers.

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