Biphenyl derivatives, their preparation and their use for...

Details Biphenyl derivatives, their preparation and their use for... Biphenyl derivatives, their preparation and their use for...

C - Chemistry, Metallurgy

07

D

C07D 233/90 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) C07D 213/80 (2006.01) C07D 235/08 (2006.01) C07D 235/26 (2006.01) C07D 239/42 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01) C07D 403/04 (2006.01) C07D 403/10 (2006.01) C07D 405/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2111662

Compounds of formula (I): (see formula I) [wherein: A represents a group (IIa), (IIb) or (IIc): (see formula IIa, IIb) (see formula IIc) R1 is alkyl, alkenyl, cycloalkyl or a group of formula R4-Y-R5-, where: R4 is hydrogen, alkyl, or cycloalkyl, R5 is a single bond or alkylene, and Y is oxygen, sulfur or imino group; R2 is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted cycloalkyl, hydroxy, amino, alkylamino, dialkylamino, formyl, alkylcarbonyl, alkoxy, alkylthio, cyano or nitro; R3 is hydrogen, alkyl, carboxy, protected carboxy, carbamoyl or tetrazol-5-yl; X is of formula -CH=, -N= or -C(COOR6)=, where R6 is hydrogen or a carboxy-protecting group; Z is a single bond, alkylene or vinylene; and B is carboxy, protected carboxy or tetrazol-5-yl]; and pharmaceutically acceptable salts and esters thereof have the ability to inhibit the action of angiotensin II and thus can be used for the treatment and prophylaxis of hypertension and cardiac diseases.

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