Biphenyl sulfonamides useful as matrix metalloproteinase...

Details Biphenyl sulfonamides useful as matrix metalloproteinase... Biphenyl sulfonamides useful as matrix metalloproteinase...

C - Chemistry, Metallurgy

07

D

C07D 279/12 (2006.01) A61K 31/54 (2006.01) A61P 9/00 (2006.01) A61P 19/00 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2371480

Inhibitors of MMP enzymes are cyclic sulfonamides of Formula I <SEE FORMULA I> or a pharmaceutically acceptable salt thereof, and cyclic sulfonamides of Formula III <SEE FORMULA III> III or a pharmaceutically acceptable salt thereof, wherein R1 and R2 include hydrogen, alkyl, and substituted alkyl; R3 and R4 include hydrogen, halo, and alkyl; X is OH or NHOH. The compounds of Formulas I and III are useful for the treatment of diseases mediated by an MMP enzyme, including cancer, osteoarthritis, rheumatoid arthritis, heart failure, and inflammation.

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