Biphenylamido derivatives as melatonergic agents

Details Biphenylamido derivatives as melatonergic agents Biphenylamido derivatives as melatonergic agents

C - Chemistry, Metallurgy

07

C

C07C 233/25 (2006.01) A61K 31/16 (2006.01) A61K 31/17 (2006.01) C07C 233/18 (2006.01) C07C 233/60 (2006.01) C07C 235/08 (2006.01) C07C 235/16 (2006.01) C07C 275/24 (2006.01) C07C 275/32 (2006.01)

Patent

CA 2251930

There is provided novel biphenylamido derivatives of formula (I) wherein Z is (II) and Y is H or Z is H and Y is (III); n is 0 or 1; R is C1-6 alkyl; R1 is C1-3 alkyl, C3-6 cycloalkyl, C1-4 alkoxymethyl, or NHR2; and R2 is C1-3 alkyl or cyclopropyl, which are melatonergic agents and are useful in the treatment of circadian rhythm-related disorders and other conditions affected by melatonin activity.

Nouveaux dérivés de biphénylamido de formule (I) dans laquelle Z est de formule (II) et Y est H ou bien Z est H et Y est de formule (III); n est 0 ou 1; R est alkyle C¿1-6?; R?1¿ est alkyle C¿3-6?, cycloalkyle C¿3-6?, alcoxyméthyle C¿1-4? ou NHR?2¿; et R?2¿ est alkyle C¿1-3? ou cyclopropyle. Lesdits dérivés sont des agents mélatonergiques et sont utiles dans le traitement des troubles liés au rythme circadien et d'autres états pathologiques associés à l'activité de la mélatonine.

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