Biphenylcarboxamide derivatives as hedgehog pathway modulators

Details Biphenylcarboxamide derivatives as hedgehog pathway modulators Biphenylcarboxamide derivatives as hedgehog pathway modulators

A - Human Necessities

61

K

A61K 31/551 (2006.01) A61K 31/167 (2006.01) A61K 31/277 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/4433 (2006.01) A61K 31/4453 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/505 (2006.01) A61K 31/5375 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2688472

The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

L'invention concerne un procédé de modulation de l'activité de la voie de signalisation Hedgehog. En particulier, l'invention concerne un procédé d'inhibition des états de croissance aberrants résultant de phénotypes tels que la perte de fonction Ptc, le gain de fonction Hedgehog, le gain de fonction Smoothened ou gain de fonction Gli, qui comprend la mise en contact d'une cellule avec une quantité suffisante d'un composé de formule I.

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