Biphenylmethane derivative and pharmacological use

Details Biphenylmethane derivative and pharmacological use Biphenylmethane derivative and pharmacological use

C - Chemistry, Metallurgy

07

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C07D 471/04 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/52 (2006.01) C07D 235/08 (2006.01) C07D 235/26 (2006.01) C07D 235/28 (2006.01) C07D 403/10 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2026533

Abstract The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. Image in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, -S-R7, -SO2-R7, -C?C-R7 or -(CH2)p-OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, -A1=A2-A3=A4- is -CH=CH-CH1=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N- or -CH=N-CH=N-, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (-COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.

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