C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/04 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07D 261/14 (2006.01) C07D 263/00 (2006.01) C07D 263/48 (2006.01) C07D 271/02 (2006.01) C07D 277/00 (2006.01) C07D 277/42 (2006.01) C07D 277/46 (2006.01) C07D 277/82 (2006.01) C07D 285/04 (2006.01) C07D 285/08 (2006.01) C07D 285/135 (2006.01) C07D 413/10 (2006.01) C07D 417/00 (2006.01) C07D 417/10 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2141792
- 192 - ABSTRACT This invention relates to a biphenylmethane derivative represented by the following formula (I): Image (I) wherein A represents a group Image or Image in which R1 represents a hydrogen atom, a lower alkyl group, a lower-cycloalkyl group, a substituted or un- substituted phenyl group, a substituted or un- substituted aralkyl group, a substituted or un- substituted acyl group or an amino acid residue; X represents an oxygen atom or a sulfur atom, Y represents a nitrogen atom or a group =CR2-, Z represents an oxygen atom, a nitrogen atom or a group =CR3-, said Y and Z not being hetero atoms at the same time, R2 and R3 each independently represents a hydrogen atom, a halogen atom, a substituted or un- substituted lower alkyl group, a protected or un- protected carboxyl group, a lower-cyclo alkyl group, a lower alkenyl group, a lower alkoxyl group, a lower alkylthio group or an aryl group or R2 and R3 may form a substituted or unsubstituted benzene ring together - 193 - with the adjacent carbon atoms; and B represents a cyano group, a protected or unprotected carboxyl group or a protected or unprotected tetrazol-5-yl group; or a salt thereof. The compound has a potent angiotensin II antagonist activity and antihypertensive effect so that it is useful as a therapeutic for circulatory diseases such as hypertension, heart diseases and cerebral apoplexy.
Amano Hirotaka
Hirata Terukage
Nomiyama Jun
Okuhira Masayasu
Sakae Nobuya
Gowling Lafleur Henderson Llp
Wakunaga Seiyaku Kabushiki Kaisha
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