C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/70 (2006.01) A01N 1/02 (2006.01) A61K 31/415 (2006.01) C07D 233/32 (2006.01) C07D 233/54 (2006.01) C07D 233/68 (2006.01)
Patent
CA 2338039
The invention relates to compounds represented by formula (I), wherein the symbols have the meanings indicated in the description, which exhibit outstanding antiarrhythmic properties and comprise a cardioprotective component. The inventive compounds can preventively inhibit or strongly reduce pathophysiological processes upon occurrence of ischemic injuries, especially ischemic cardiac arrhythmia. Said compounds also exhibit a strong inhibiting effect on cellular proliferation.
Des composés de la formule (I), dans laquelle les symboles ont les significations indiquées dans les revendications, possèdent de remarquables propriétés anti-arythmiques et présentent un constituant cardioprotecteur. Ils peuvent préventivement inhiber ou réduire fortement les processus pathophysiologiques lors de l'apparition de lésions d'origine ischémique, notamment lors du déclenchement d'arythmies cardiaques d'origine ischémique. Ils présentent en outre un puissant effet inhibiteur sur la prolifération cellulaire.
Kleemann Heinz-Werner
Lang Hans Jochen
Petry Stefan
Schwark Jan-Robert
Weichert Andreas
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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