C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/292, 260/325
C07D 295/08 (2006.01) C07D 295/04 (2006.01) C07D 295/092 (2006.01)
Patent
CA 1072552
ABSTRACT OF THE DISCLOSURE Novel biphenyl ethers of the formula Image wherein Rl, R2 and R3 are each H or CH3; R4 is H, F, Cl, Br or CF3; when R2 = R3 = H, Z is piperidino or morpholino each of which is monosubstituted or polysubstituted by alkyl of 1-4 carbon atoms, and when R2 - CH3, Z is morpholino, pyrrolidino, homopiperidino or piperidino which is unsubstituted or mono- æubstituted or polysubstituted by alXyl of 1-4 carhon atoms or by hydroxyl; and particularly wherein Rl is H, F, Cl, Br or CF3; and Z is pyrrolidino, homopiperidino or piperidino which is unsubstituted or monosubstituted or polysab- stituted by alkyl of 1-4 carbon atoms or by hydroxyl; and their physiologically acceptably acid addition salts are prsvided herein. They exhibit pharmaceutically useful serum cholesterol and triglyceride lowering. fibrinolytic, thermbocyr aggregation inhibition .beta.-receptor blocking and neuroleptic effects.
245224
Jonas Rochus
Lissner Reinhard
Mehrhof Werner
Nowak Herbert
Schacht Erich
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