C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/245, 167/254
C07C 69/65 (2006.01) C07D 307/32 (2006.01) C07D 307/33 (2006.01) C07D 309/28 (2006.01)
Patent
CA 1240333
Abstract Biphenylylpropionic acid derivatives of the formula: Image wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula: Image wherein R1 is a lower alkyl group having 1 to 5 carbon atoms and R2 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, or a lactone having the formula: Image wherein R3 and R4 are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms, and n is an integer of 1 or 2. The compounds have excellent anti-inflammatory, analgesic and antipyretic activities. Moreover, the compounds have no irritation, rapid and long-acting, and high safety margin.
436223
Masumoto Shozo
Mimura Mitsuo
Okumura Makoto
Tohno Masao
Uchida Katsuhiro
Kaken Pharmaceutical Co. Ltd.
Osler Hoskin & Harcourt Llp
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