Bipodal ligand-metal ion chelates

Details Bipodal ligand-metal ion chelates Bipodal ligand-metal ion chelates

C - Chemistry, Metallurgy

07

F

C07F 9/30 (2006.01) A61K 49/00 (2006.01) A61K 49/10 (2006.01) A61K 51/04 (2006.01) C07F 13/00 (2006.01)

Patent

CA 2246204

The invention relates to complexes comprising a metal ion and chelating ligands which incorporate a bipodal backbone. More particularly, the invention pertains to bipodal ligand bis-{[bis-(carboxymethyl)-amino]-methyl}- phosphinic acid (H5xuta) which forms novel coordination compounds with a variety of metal ions, particularly, but not exclusively, trivalent metal ions and lanthanide metal ions, which are useful in nuclear medicine. The process comprises complexing Tc or Re or any one of the group 13 metals, Al, Ga and In, and any one of the rare earths, Sc, Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu, with the H5xuta bipodal ligand.

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