Bipolar lipids capable of delivering polyanions to cells

Details Bipolar lipids capable of delivering polyanions to cells Bipolar lipids capable of delivering polyanions to cells

C - Chemistry, Metallurgy

07

C

C07C 235/12 (2006.01) A61K 31/16 (2006.01) A61K 47/48 (2006.01) C07C 235/10 (2006.01) C07C 237/10 (2006.01) C07C 271/20 (2006.01)

Patent

CA 2327465

Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.

L'invention porte sur des lipides bipolaires capables de former des complexes avec des polyanions. Lesdits lipides, qui comportent une tête cationique liée à un squelette hydrophobe et une queue hydrophile, et peuvent s'auto-assembler pour former des complexes stables dans des solutions aqueuses, s'utilisent en particulier pour distribuer des substances bioactives telles que des acides nucléiques à des cellules, in vitro ou in vivo.

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