C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/08 (2006.01) A61K 31/40 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2607940
The present invention is directed towards an isomer, an enantiomer, a diastereoisomer, or a tautomer of a pyrrolidine compound represented by Formula (I) in which the substituents R1, R1a, R2, R2a, R3, A and Q are defined herein; or a prodrug, or a salt thereof, and which bind to IAP BIR domains. In particular, the compounds are useful in treating proliferative disorders such as cancer.
La présente invention porte sur un isomère, un énantiomère, un diastéréoisomère, ou un tautomère d'un composé de pyrrolidine représenté par la formule (I) dans lequel les substituants R1, R1a, R2, R2a, R3, A et Q sont définis dans la description ; ou un promédicament, ou sel de celui-ci, et qui se lient aux domaines IAP BIR. En particulier, les composés sont utiles dans le traitement des troubles prolifératifs tels que le cancer.
Boudreault Alain
Bureau Patrick
Jaquith James
Jarvis Scott
Labit Delphine
Aegera Therapeutics Inc.
Pharmascience Inc.
Ridout & Maybee Llp
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