Bir domains of mammalian iap gene family

Details Bir domains of mammalian iap gene family Bir domains of mammalian iap gene family

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2403947

Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided. In particular, disclosed are BIR domains from IAP polypeptides, nucleic acids encoding the BIR domains, and uses of the BIR domains for inhibiting apoptosis.

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