C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/29 (2006.01) A61K 39/36 (2006.01) C07K 1/22 (2006.01) C07K 14/415 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2067182
2067182 9203551 PCTABS00011 The invention provides recombinant DNA molecules which code for polypeptides that exhibit the antigenicity of a P14 allergen of birch Betula verrucosa and other plants of the order Fagales, and for polypeptides comprising at least one epitope thereof, as well as nucleic acids which under stringent conditions hybridize with such DNA sequences or are derivable from such sequences by degeneracy of the genetic code. A method is provided that permits purification of P14 allergens or cross-reactive allergens by means of binding to poly(L-proline). In addition, methods are described for making the proteins and polypeptides coded by these DNA molecules and their use in the diagnosis or therapy of allergic diseases.
Breitenbach Michael
Duchene Michael
Kraft Dietrich
Pettenburger Karin
Rumpold Helmut
Biomay Produktions- Und Handelsgesellschaft M.b.h.
Perley-Robertson Hill & Mcdougall Llp
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