Bis(2,2-dimethyl-1-aziridinyl)phosphinic amides for use in...

Details Bis(2,2-dimethyl-1-aziridinyl)phosphinic amides for use in... Bis(2,2-dimethyl-1-aziridinyl)phosphinic amides for use in...

C - Chemistry, Metallurgy

07

F

260/338

C07F 9/564 (2006.01)

Patent

CA 1205080

NOVEL BIS(2,2-DIMETHYL-1-AZIRIDINYL)PHOSPHINIC AMIDE ANTINEOPLASTIC AGENTS AND A METHOD FOR THEIR PREPARATION ABSTRACT Novel bis(2,2-dimethyl-1-aziridinyl)phosphinic amide antineoplastic agents are disclosed of the formula: Image wherein R and R' are both methyl or are independently hydrogen or substituted alkyl of 1-10 carbon atoms, wherein each substituent is selected from the group consisting of amine and alkoxy, said compounds being the product of a process comprising reacting a P, P-bis(2,2-diemethyl-1-aziridinyl)phosphinic halide of the formula: Image with an amine of the formula: Image wherein hal is selected from chlorine, fluorine, bromine and iodine and R and R' are as previously described. - 1 -

430746

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