Bis-(2-ammonium-2-hydroxymethyl-1,3-propanediol) (2r-...

Details Bis-(2-ammonium-2-hydroxymethyl-1,3-propanediol) (2r-... Bis-(2-ammonium-2-hydroxymethyl-1,3-propanediol) (2r-...

C - Chemistry, Metallurgy

07

F

260/369.7

C07F 9/38 (2006.01) C07F 9/655 (2006.01)

Patent

CA 1108631

ABSTRACT OF THE DISCLOSURE This invention discloses a novel antibiotic compound and a process for the preparation thereof. The compound is bis-(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2R-cis)- (3-methyloxiranyl)-phosphonate and the process comprises reacting (2R-cis)-(3-methyloxiranyl)phosphonic acid or a salt thereof with 2-amino-2-hydroxymethyl-1,3-propanediol or a salt thereof. The new salt shows remarkably increased tolerance levels and bioavailability over the calcium and sodium salts presently in use.

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