C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 7/08 (2006.01) A61K 31/695 (2006.01) C09K 15/32 (2006.01)
Patent
CA 2046050
The present invention relates to certain bis[4-(2,6- dialkyl)phenol]silane derivatives of the formula: (see formula I) wherein R1, R2, R3 and R4 are each independently a C1-C6 alkyl group; Z is a thio, oxy or methyl.ene group; and A is a C1-C4 alkylene group; which are useful as inhibitors of LDL lipid peroxidation and as antiatherosclerotic agents.
Mao Simon J. T.
Parker Roger A.
Aventis Pharma Inc.
Merrell Dow Pharmaceuticals (canada) Inc.
Osler Hoskin & Harcourt Llp
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