Bis(4-demethoxydaunorubicin)dihydrazone derivatives and...

Details Bis(4-demethoxydaunorubicin)dihydrazone derivatives and... Bis(4-demethoxydaunorubicin)dihydrazone derivatives and...

C - Chemistry, Metallurgy

07

H

260/208.1

C07H 15/24 (2006.01) C07H 15/252 (2006.01)

Patent

CA 1137471

BIS(4-DEMETHOXYDAUNORUBICIN)DIHYDRAZONE DERIVATIVES AND PHARMACOLOGICALLY ACCEPTABLE SALTS THEREOF Abstract of the Disclosure The present invention relates to bis(4-demethoxydauno- rubicin)dihydrazone of the formula Image wherein R1 and R2 represent hydrogen or alkyl having from 1 to 4 carbon atoms and X represents (a) alkylene having from 3 to 20 carbon atoms and optionally substituted by one or more hydroxy and/or primary amino groups, or -1- (b) alkylene optionally interrupted by one of more secondary amino groups, the total number of carbon and nitrogen atoms in the resultant chain being 3 to 20 and to pharmacologically acceptable salts thereof which are potent inhibitors of neoplastic disease and are also useful as antiviral agents.

351196

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