Bis-amino acid hydroxyethylamino sulfonamide retroviral...

Details Bis-amino acid hydroxyethylamino sulfonamide retroviral... Bis-amino acid hydroxyethylamino sulfonamide retroviral...

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/05 (2006.01) C07K 5/062 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2215025

Selected bis-amino acid hydroxyethylamino sulfonamide compounds of formula (I) are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and the treatment of a retroviral infection.

L'invention porte sur une sélection de composés du type hydroxyéthylamino sulfonamide de bis aminoacide de formule (I) s'avérant efficaces comme inhibiteurs de protéases rétrovirales et notamment de celle du VIH, sur lesdits inhibiteurs de protéases rétrovirales, et plus particulièrement sur de nouveaux composés sélectionnés, une composition et un procédé d'inhibition des protéases rétrovirales telle que celle du VIH humain, de prévention prophylactique et de traitement des infections rétrovirales, et de prévention de la dissémination d'un rétrovirus.

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