Bis-amino acid sulfonamides containing n-terminally a...

Details Bis-amino acid sulfonamides containing n-terminally a... Bis-amino acid sulfonamides containing n-terminally a...

C - Chemistry, Metallurgy

07

K

C07K 5/062 (2006.01) A61K 38/05 (2006.01) A61P 31/18 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2353088

This invention relates generally to bis-amino acid sulfonamides containing substituted benzyl amines of formula (I) or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as HIV protease inhibitors, pharmaceutical compositions and diagnostic kits comprising the same, methods of using the same for treating viral infection or as assay standards or reagents, and intermediates and processes for making the same.

La présente invention concerne, de manière générale, des bis-aminoacides sulfamides renfermant des benzylamines substituées de formule 1, ou des formes ou des mélanges stéréoisomères de ceux-ci ou leurs formes de sels pharmaceutiquement acceptables, lesquels composés sont utilisés comme inhibiteurs de la protéase du VIH. L'invention concerne également des compositions pharmaceutiques et des trousses de diagnostic les comprenant, des procédés d'utilisation de celles-ci dans le traitement d'infections virales ou comme étalons ou réactifs de bioanalyse, ainsi que leurs intermédiaires et procédés de fabrication.

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