Bis- and mono-quaternary ammonium derivatives of 2.beta.,...

C - Chemistry – Metallurgy – 07 – J

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260/20

C07J 43/00 (2006.01)

Patent

CA 1153366

1 ABSTRACT The invention relates to novel bisquaternary ammonium derivatives of 2.beta.,16.beta.-dipiperidino-5.alpha.- androstanes having the formula: Image .2X- wherein Image ; R2 = CH3, C2H5 or CH2CH=CH2; R3 = CH3, C2H5 or CH2CH=CH2, with the proviso that R2 and R3 are not CH3 simultaneously; R4 = O or H(.beta.OR5), wherein R5 = H or aliphatic carbacyl (1-6 C); and X = a halogen atom, to processes for their preparation and to pharmaceutical preparations. The invention also relates to novel 16-monoquaternary analogs as intermediates. The compounds possess neuromuscular blocking activity.

366536

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