Bis aromatic compounds for use as ltc4 synthase inhibitors

Details Bis aromatic compounds for use as ltc4 synthase inhibitors Bis aromatic compounds for use as ltc4 synthase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/50 (2006.01) A61K 31/4406 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) C07D 213/65 (2006.01) C07D 213/74 (2006.01) C07D 401/10 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2754781

There is provided compounds of formula (I), wherein E1, E2a, E2b, E2c, E4, D1, D2, D3, L1, Y1, L2 and Y2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.

La présente invention concerne des composés représentés par la formule (I), dans laquelle E1, E2a, E2b, E2c, E4, D1, D2, D3, L1, Y1, L2 et Y2 ont les significations telles que données dans la description, et des sels pharmaceutiquement acceptables de ces composés. Les composés se révèlent utiles pour le traitement de maladies dans lesquelles l'inhibition de la leucotriène C4 synthase est souhaitée et/ou nécessaire, et particulièrement pour le traitement d'une affection respiratoire et/ou d'une inflammation.

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