Bis-aromatic compounds useful in the treatment of inflammation

Details Bis-aromatic compounds useful in the treatment of inflammation Bis-aromatic compounds useful in the treatment of inflammation

C - Chemistry, Metallurgy

07

C

C07C 237/40 (2006.01) A61K 31/166 (2006.01) A61K 31/194 (2006.01) C07C 59/90 (2006.01) C07C 65/40 (2006.01) C07C 233/75 (2006.01)

Patent

CA 2698847

There is provided compounds of formula (I): wherein Y, ring A, D1, D2, D3, L1, Y1, L2, Y2, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.

L'invention concerne des composés représentés par la formule (I): dans laquelle Y, et les motifs A, D1, D2, D3, L1, Y1, L2, Y2, L3 et Y3dont les significations sont comme indiquées dans le descriptif, ainsi que des sels de qualité pharmaceutique de ces composés. Ces composés conviennent pour le traitement de maladies dans laquelle l'inhibition de la leulkotriène C4 synthase est souhaitable ou requise, en particulier pour le traitement de troubles respiratoires et/ou d'inflammations.

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