Bis-aryl amide compounds and methods of use

Details Bis-aryl amide compounds and methods of use Bis-aryl amide compounds and methods of use

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/44 (2006.01) A61P 29/00 (2006.01) C07D 213/00 (2006.01) C07D 237/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 407/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2618393

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including autoimmune disease and inflammation. In one embodiment, the compounds have a general Formula (I) wherein A1, A2, A3, A4, L, R1, R2 and R3 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of the present invention, methods of use such as treatment of Lck and/or c-Kit kinase mediated diseases by administering the compounds of the invention, or compositions including one or more compounds of the invention, and intermediates and processes useful for the preparation of compounds of the present invention.

L'invention concerne une nouvelle classe de composés utilisés pour la prophylaxie et le traitement de maladies médiées par la protéine kinase, telles que les maladies auto-immunes et l'inflammation. Dans un mode de réalisation, les composés possèdent la formule générale (I) dans laquelle A1, A2, A3, A4, L, R1, R2 et R3 sont tels que définis dans la spécification. L'invention se rapporte également à des compositions pharmaceutiques renfermant un ou plusieurs composés de l'invention, à des procédés d'utilisation destinés à traiter des maladies médiées par la Lck et/ou la c-Kit kinase par l'administration des composés précités ou de compositions renfermant un ou plusieurs des composés précités, et à des intermédiaires et procédés utilisés dans la préparation des composés de l'invention.

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