Bis-aryl amide compounds and methods of use

Details Bis-aryl amide compounds and methods of use Bis-aryl amide compounds and methods of use

C - Chemistry, Metallurgy

07

D

C07D 215/20 (2006.01) A61K 31/47 (2006.01) A61K 31/496 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2750864

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including autoimmune disease and inflammation. In one embodiment, the compounds have a general Formula I (see formula I) wherein A1, A2, A3, A4, L, R1, R2 and R3 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of the present invention, methods of use such as treatment of Lck and/or c-Kit kinase mediated diseases by administering the compounds of the invention, or compositions including one or more compounds of the invention, and intermediates and processes useful for the preparation of compounds of the present invention.

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