Bis-aryl sulfonamides

Details Bis-aryl sulfonamides Bis-aryl sulfonamides

C - Chemistry, Metallurgy

07

C

C07C 311/21 (2006.01) A61K 31/18 (2006.01) A61P 29/00 (2006.01) C07D 213/26 (2006.01) C07D 213/50 (2006.01) C07D 213/70 (2006.01) C07D 213/74 (2006.01) C07D 213/84 (2006.01) C07D 213/89 (2006.01) C07D 241/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2505590

Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor- mediated diseases, and as controls in assays for the identification of chemokine antagonists.

L'invention concerne des composés qui constituent des antagonistes puissants des récepteurs des chimiokines. Ces composés, généralement des dérivés d'aryle sulfonamide, sont utiles dans des compositions pharmaceutiques, des méthodes de traitement de maladies dans lesquelles interviennent les récepteurs des chimiokines, et comme témoins dans des techniques visant à identifier des antagonistes des chimiokines.

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