Bis-aryl urea compounds for the treatment of protein...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 239/48 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01) C07D 213/81 (2006.01) C07D 239/42 (2006.01) C07D 239/74 (2006.01) C07D 251/18 (2006.01) C07D 403/12 (2006.01) C07D 417/12 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2619366

The present invention relates to compounds of Formulas (I) and (II), wherein A1, A2, B1, B2, Q, X1, X2, Y and R3 are defined herein, synthetic intermediates, and pharmaceutical compositions, comprising such compounds. The compounds and compositions are capable of modulating various protein kinase receptors such as Tie-2 and, therefore, influencing kinase related disease states and conditions. The compounds, for example, are capable of treating cancer caused by unregulated angiogenesis, and inflammation as well as other proliferative disorders.

La présente invention concerne des composés des formules (I) et (II), selon lesquelles A1, A2, B1, B2, Q, X1, X2, Y et R3 sont tels que spécifiés ci-après, des intermédiaires synthétiques et des compositions pharmaceutiques contenant ces composés. Lesdits composés et compositions peuvent moduler divers récepteurs de la protéine kinase, tels que Tie-2, ce qui permet d'influencer des états et des troubles de la maladie liée à la kinase. Les composés, par exemple, peuvent traiter un cancer provoqué par une angiogenèse non régulée et une inflammation, ainsi que par d'autres troubles prolifératifs.

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