Bis-basic compounds as tryptase inhibitors, processes for...

Details Bis-basic compounds as tryptase inhibitors, processes for... Bis-basic compounds as tryptase inhibitors, processes for...

C - Chemistry, Metallurgy

07

C

C07C 257/18 (2006.01) A61K 31/155 (2006.01) A61K 31/4545 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01) C07D 211/26 (2006.01)

Patent

CA 2391085

The present invention relates to bis-basic compounds of general formula (I) B1-Ar1-X1-Ar2-X2-A-X3-Ar3-X4-Ar4-B2 (I) wherein the groups B1, B2, Ar1, Ar2, Ar3, Ar4, X1, X2, X3, X4 and A may have the meanings given in the foregoing specification and in the claims, processes for preparing them and their use as pharmaceutical compositions, particularly as pharmaceutical compositions with a tryptase-inhibiting activity.

La présente invention concerne des composés bis-basiques de formule générale (I): B<1>-Ar<1>-X<1>-Ar<2>-X<2>-A-X<3>-Ar<3>-X<4>-Ar<4>-B<2>, dans laquelle les restes B<1>, B<2>, Ar<1>, Ar<2>, Ar<3>, Ar<4>, X<1>, X<2>, X<3>, X<4> et A peuvent avoir la signification donnée dans le descriptif et les revendications, un procédé de fabrication des ces composés, et leur utilisation en tant que médicament, en particulier en tant que médicament ayant une activité inhibitrice de tryptase.

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