C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/223, 260/266
C07D 241/08 (2006.01) A61K 31/495 (2006.01) C07D 405/14 (2006.01)
Patent
CA 1305484
ABSTRACT OF THE DISCLOSURE Disclosed is a process for preparation of novel bis-dioxopiperazine derivatives represented by the following formula (I): Image ...(I) wherein R1 represents a lower alkyl group; R2 represents a hydrogen atom or a group of -CH2-O-?-R3; and R3 represents a lower alkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted furyl group, a substituted or unsubstituted styryl group or a group of -(CH2)n-R4, Image or -OR7 in which R4 represents a carboxyl group, a substituted or unsubstituted phenyl group or a substituted or unsubstituted phenoxy group, R5 and R6 respectively represent a hydrogen atom or a protective group for amino group, R7 represents a lower alkyl group or a substituted or unsubstituted benzyl group, and n is an integer and 1 or 2, a substituent for the phenyl group, the phenoxy group and the benzyl group being selected from the group consisting of a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, an amino group and a cyano group, a substituent for the phenyl group, the furyl group and the styryl group being selected from the group consisting of a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, an amino group and a cyano group.
536472
Cai Jun-Chao
Takase Muneaki
Fetherstonhaugh & Co.
Zenyaku Kogyo Kabushiki Kaisha
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