Bis-esters of dicarboxylic acids with amoxicillin and...

Details Bis-esters of dicarboxylic acids with amoxicillin and... Bis-esters of dicarboxylic acids with amoxicillin and...

C - Chemistry, Metallurgy

07

D

260/114.7

C07D 499/68 (2006.01) C07D 499/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 1199909

BIS-ESTERS OF DICARBOXYLIC ACIDS WITH AMOXICILLIN AND CERTAIN HYDROXYMETHLPENICILLANATE 1,1-DIOXIDES Abstract Antibacterial bis-esters of 1,4-cyclohexanedi- carboxylic acids and alkane dicarboxylic acids wherein the ester moieties are derived from different alcohols; one alcohol being hydroxymethylpenicillanate 1,1-dioxide, or the 6-beta-hydroxymethyl or the 6- alpha-aminomethyl derivative thereof; and the other being 6-[D-(2-amino-2-(p-hydroxyphenyl)acetamido)]- penicillanic acid (amoxicillin); and pharmaceutically acceptable salts thereof; a method for the use of said esters and their salts, and methods for their preparation.

450835

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