C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 225/36 (2006.01) A61K 31/135 (2006.01) A61K 31/155 (2006.01) A61K 31/165 (2006.01) A61K 31/27 (2006.01) A61K 31/335 (2006.01) C07C 225/34 (2006.01) C07C 229/74 (2006.01) C07C 237/48 (2006.01) C07C 271/12 (2006.01) C07C 335/32 (2006.01) C07D 303/36 (2006.01)
Patent
CA 2072889
2072889 9207557 PCTABS00013 The present invention provides novel substituted anthraquinones having formula (.alpha.), wherein R1 and R2 are independently H, C1-C10 alkyl, aryl, arylalkyl, alkylaryl, or R1 and R2 taken together with the adjacent nitrogen atom N form a substituted or unsubstituted cyclic ring which may contain additional heteroatoms; n and m are independently 1, 2, or 3; A is halogen, OH, alkoxy, OCO(NR3R4), S-C(NH2)=NR5, or when m = 1, comprises an oxirane ring with the adjacent oxygen atom; R3, R4, and R5 are independently H, alkyl, or aryl; X is H, OH, NR6R7, Cl, Br, I, F, alkyl, aryl, alkoxy, aryloxy, COOR8, or CONR9R10; and R6, R7, R8, R9, and R10 are independently H, lower alkyl, or aryl useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.
Jiang Jack B.
Johnson Mary G.
Borden Ladner Gervais Llp
Jiang Jack B.
Johnson Mary G.
Sphinx Pharmaceuticals Corporation
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