Bis-(hydroxymethyl) cyclobutyl purines and pyrimidines

Details Bis-(hydroxymethyl) cyclobutyl purines and pyrimidines Bis-(hydroxymethyl) cyclobutyl purines and pyrimidines

C - Chemistry, Metallurgy

07

D

167/125, 167/220

C07D 239/24 (2006.01) A61K 31/513 (2006.01) A61K 31/52 (2006.01) C07C 35/04 (2006.01) C07D 239/50 (2006.01) C07D 239/54 (2006.01) C07D 239/545 (2006.01) C07D 239/553 (2006.01) C07D 473/00 (2006.01) C07D 487/04 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1341201

Antiviral activity is exhibited by compounds having the formula (See formula I) and its pharmaceutically acceptable salts wherein R1 is (See formula II) ( See formula III) (SEE formula IV) (See formula V) (See formula VI) (See formula VII) (See formula VIII) (See formula IX) (See formula X) (See formula XI) (See formula XII) (See formula XIII) (See formula XIV) (See formula XV) (See formula XVI) (See formula XVII) wherein R2 is hydrogen, methyl, fluoro, chloro, bromo, iodo, hydroxy or amino; R3 is fluoro, chloro, bromo, iodo, hydrogen, methyl, trifluoro-methyl, ethyl, n-propyl, 2-fluoroethyl, 2-chloro-ethyl, or Image trans wherein R4 is chloro, bromo, iodo, hydrogen methyl or trifluoromethyl; R5 is alkyl; R6 is hydrogen, alkyl, substituted alkyl, or aryl; and R7 and R8 are independently hydrogen, -PO3H2 or Image

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