Bis isoquinolinium compositions and methods of use

Details Bis isoquinolinium compositions and methods of use Bis isoquinolinium compositions and methods of use

C - Chemistry, Metallurgy

07

D

260/277.3

C07D 217/20 (2006.01) C07C 51/41 (2006.01) C07D 217/10 (2006.01)

Patent

CA 1125287

CHEMICAL COMPOUNDS, METHODS AND PREPARATION Abstract of the Disclosure Intermediate-duration, reversible neuromuscular blocking agents of the formula (I) Image (I) where B and C are preferably para or may be meta and are each Image where W is CH2 or most preferably CH = CH, R1, R2, R3 and R4 are the same or different and are each hydrogen or lower alkoxy of 1 to 4 carbon atoms and preferably methoxy, Y is lower alkyl of 1 to 4 carbon atoms and preferably methyl, Z is hydrogen, lower alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, benzyl, or Image where ALKYL has 1 to 4 carbon atoms preferably where the O-ALKYL is at the 2, 3, 4 or 5 positions such as 4-methoxybenzyl and is most preferably 3,4-dimethoxy- benzyl or 3,4,5-trimethoxybenzyl, n is 2, 3 or 4, most preferably 2 or 3 provided that at least one of R1 to R4 is lower alkoxy and most preferably where R1 and R4 are hydrogen and R2 and R3 are methoxy and X is a pharmaceutically acceptable anion. The neuromuscular blocking agents of formula I are useful for administration to a patient to cause skeletal muscle relaxion during surgery and are normally administered intravenously in a pharmaceutically acceptable carrier.

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