Bis(nitrosoureido)-polyol derivatives and process for their...

Details Bis(nitrosoureido)-polyol derivatives and process for their... Bis(nitrosoureido)-polyol derivatives and process for their...

C - Chemistry, Metallurgy

07

D

260/540.95

C07D 317/28 (2006.01) C07C 275/68 (2006.01)

Patent

CA 1108182

ABSTRACT OF THE DISCLOSURE The invention relates to bis(nitrosoureido)-polyol derivatives of general formula I B1 - A - B2 (I) wherein A stands for an open chain polyol comprising 4 to 6 carbon atoms or a six-membered cyclic polyol, and B1 and B2 being attached to two different carbon atoms of the chain A, are identical or different, and stand for a group of general formula II Image (II) wherein X stands for a halogen atom and Y and Z stand for a hydrogen atom or a nitroso group, with the restriction, that in B1 and B2 Y and Z must be different. A process for the preparation of the compounds of general formula I is also within the scope of this invention. The above compounds possess valuable cytostatic activity.

307574

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