Bis-ortho-substituted benzoylguanidines, processes for their...

C - Chemistry – Metallurgy – 07 – C

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C07C 279/22 (2006.01) A61K 31/16 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 311/47 (2006.01) C07C 317/32 (2006.01) C07C 323/44 (2006.01) C07D 207/30 (2006.01) C07D 295/26 (2006.01) C07D 307/34 (2006.01) C07D 333/04 (2006.01)

Patent

CA 2206198

Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a medicament or diagnostic, and medicament containing them Bis-ortho-substituted benzoylguanidines of the formula I Image I in which R(1) to R(5) have the meanings indicated in the claims, are suitable asantiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment, and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes in theformation of ischemically induced damage, in particular in the elicitation of ischemically induced cardiac arrhythmias.

Benzoylguanidines bis-ortho-substituées, procédés de préparation, utilisation comme médicament ou produit diagnostique, et médicament contenant ces composés. Les benzoylguanidines bis-ortho-substituées de formule I Image I, où R(1) à R(5) ont les significations indiquées dans les revendications, conviennent comme produits pharmaceutiques antiarythmisants ayant un constituant cardioprotecteur pour la prévention et le traitement de l'infarctus et pour le traitement de l'angine de poitrine. Ils inhibent également, de manière préventive, les processus patho-physiologiques de la formation des lésions induites par l'ischémie, en particulier le déclenchement des arythmies cardiaques induites par l'ischémie.

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