C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/38 (2006.01) A61K 31/66 (2006.01) C07F 9/40 (2006.01)
Patent
CA 2284704
The present invention relates to conjugates of 3-carboxy-4,4'- dihydroxyphosphorylbutenoic acids with alkylating agents. Such derivatives are endowed with marked antitumor activity, especially against multiple myeloma. The present invention relates as well to a process for the preparation thereof and to pharmaceutical compositions containing them.
La présente invention concerne des conjugués d'acides 3-carboxy-4,4'-dihydroxyphosphorylbuténoïques avec des agents alcoylants. De tels dérivés sont dotés d'une activité antitumorale prononcée, notamment contre le myélome multiple. La présente invention concerne également un procédé de préparation de ces conjugués, de même que des compositions pharmaceutiques les contenant.
Conti Marco
D'alo' Simonetta
Livi Valeria
Menta Ernesto
Spinelli Silvano
Kirby Eades Gale Baker
Novuspharma S.p.a.
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