Bis-(piperazinyl or homopiperazinyl)-alkanes

Details Bis-(piperazinyl or homopiperazinyl)-alkanes Bis-(piperazinyl or homopiperazinyl)-alkanes

C - Chemistry, Metallurgy

07

D

260/266.2, 260/2

C07D 241/04 (2006.01) C07D 243/08 (2006.01) C07D 295/02 (2006.01) C07D 295/04 (2006.01) C07D 295/073 (2006.01) C07D 295/084 (2006.01) C07D 295/088 (2006.01) C07D 295/096 (2006.01) C07D 295/108 (2006.01) C07D 295/145 (2006.01) C07D 295/185 (2006.01) C07D 403/06 (2006.01)

Patent

CA 1218652

ABSTRACT Bis(piperazinyl or homopiperazinyl) alkanes Compounds of formula I Image (I) wherein R1, R2, R3, R4, R5 and R6, which may be identical to or different from each other, are each hydrogen, alkyl of 1 to 4 carbon atoms, hydroxyl, alkoxy of 1 to 4 carbon atoms, alkanoyloxy of upto 4 carbon atoms, halogen, trihalomethyl, di(lower alkyl of 1 to 4 carbon atoms)-amino, (alkoxy of 1 to 4 carbon atoms)-carbonyl, nitro, cyano or alkanoyl of upto 3 carbon atoms; R7 and R8, which may be identical to or different from each other, are each hydrogen, methyl, hydroxyl, carboxyl, (alkoxy of 1 to 4 carbon atoms)-carbonyl, hydroxymethyl, phenyl or p-chlorophenyl; R9 and R10 are each hydrogen or methyl; j and k are integers from 0 to 3, their sum being no more than 4; m and n are integers from 0 to 3, their sum being no more than 4; A is -CH2- or -CH2-CH2-; or R7 and R9 together or R8 and R10 together are oxo, provided k or m is other than 0; or R7 and R9 together and R8 and R10 together are oxo, provided k and m are other than 0; R11 and R12, which may be the same or different, represent hydrogen or, when A represents a group -CH2-, each represents from one to four methyl substituents on the carbon atoms of the piperazine ring; R13, R14, R15 and R16, which may be identical to or different from each other, are each hydrogen or methyl, or R13 and R14 together and/or R15 and R16 together are oxo; and X is alkylene of 1 to 2 carbon atoms, optionally hydroxy-substituted) and acid addition salts thereof. The compounds as well as their pharmacologically acceptable salts are useful as antiallergics and anti-inflammatories.

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