Bis-sulfonomides hydroxamic acids as mmp inhibitors

Details Bis-sulfonomides hydroxamic acids as mmp inhibitors Bis-sulfonomides hydroxamic acids as mmp inhibitors

C - Chemistry, Metallurgy

07

C

C07C 311/19 (2006.01) A61K 31/18 (2006.01) C07C 311/29 (2006.01)

Patent

CA 2274889

The present invention provides a compound of formula (I) or pharmaceutically acceptable salts thereof wherein R1 and R2 are the same or different and are C1-10alkyl, phenyl, hetero-aryl, or phenyl substituted with C1-4alkyl, OR3, NHR3, CONHR3, NHCOR3, or halo; wherein R3 is H, or C1-4alkyl; and n is 1, 2, 3, 4, 5 or 6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.

La présente invention concerne un composé de la formule (I) ou des sels de ce composé acceptables du point de vue pharmaceutique; dans la formule (I) de l'invention, R?1¿ et R?2¿ sont identiques ou différents et représentent un alkyle en C¿1-10?, un phényle, un hétéro-aryle, ou un phényle substitué par un alkyle en C¿1-4?, OR?3¿, NHR?3¿, CONHR?3¿, NHCOR?3¿, ou un halo; R?3¿ représente H, ou un alkyle en C¿1-4?; et n représente 1, 2, 3, 4, 5, ou 6. Les composés sont des inhibiteurs de métalloprotéinases matricielles impliquées dans la dégradation de tissus.

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