Bis-(sulfonylamino) derivatives for use in therapy

Details Bis-(sulfonylamino) derivatives for use in therapy Bis-(sulfonylamino) derivatives for use in therapy

C - Chemistry, Metallurgy

07

D

C07D 307/79 (2006.01) A61K 31/18 (2006.01) A61K 31/341 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/404 (2006.01) A61K 31/4155 (2006.01) A61K 31/4245 (2006.01) A61K 31/426 (2006.01) A61K 31/4402 (2006.01) A61K 31/4418 (2006.01) A61K 31/505 (2006.01) A61P 29/00 (2006.01) C07C 311/44 (2006.01) C07D 209/10 (2006.01) C07D 213/30 (2006.01) C07D 213/64 (2006.01) C07D 233/96 (2006.01) C07D 271/10 (2006.01) C07D 277/32 (2006.01) C07D 307/10 (2006.01) C07D 307/38 (2006.01) C07D 333/34 (2006.01) C07D

Patent

CA 2709510

The invention provides compounds of formula (I) wherein R1,R3,L1,L2,G1,G2, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of microsomal prostaglandin E synthase-1.

L'invention porte sur des composés représentés par la formule (I), dans laquelle R1, R3, L1, L2, G1, G2, A et m sont tels que définis dans la description et sur leurs isomères optiques, racémates et tautomères, et sur des sels pharmaceutiquement acceptables de ceux-ci. L'invention porte également sur des procédés permettant de préparer les composés, sur des compositions pharmaceutiques les contenant et sur leur utilisation en thérapie. Les composés sont des inhibiteurs de la prostaglandine E synthase-1 microsomale.

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