C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/51 (2006.01) A61K 31/145 (2006.01) A61P 19/00 (2006.01) C07D 209/42 (2006.01) C07D 213/04 (2006.01) C07D 213/78 (2006.01) C07D 231/14 (2006.01) C07D 263/57 (2006.01) C07D 277/56 (2006.01) C07D 277/64 (2006.01) C07D 307/68 (2006.01) C07D 307/79 (2006.01) C07D 333/38 (2006.01) C07D 333/52 (2006.01) C07D 405/04 (2006.01) C07D 409/06 (2006.01) C07D 417/04 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2705755
The invention provides compounds of formula wherein R1, R2, L1, L2, G1, G2, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of microsomal prostaglandin E synthase-1.
La présente invention concerne des composés représentés par la formule I. Dans cette formule, R1, R3, L1, L2, G1, G2, A et m sont tels que définis dans la spécification, et des isomères optiques, des racémates et des tautomères de ceux-ci ainsi que des sels pharmaceutiquement acceptables de ceux-ci, avec des processus pour leur préparation, des compositions pharmaceutiques contenant ces composés et leur utilisation en thérapie. Ces composés sont des inhibiteurs de prostaglandine E synthase -1 microsomale.
Bylund Johan
Ek Maria
Holenz Joerg
Johansson Martin H.
Kers Annika
Astrazeneca Ab
Fetherstonhaugh & Co.
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