Bis-thymosine .alpha.-1compounds

Details Bis-thymosine .alpha.-1compounds Bis-thymosine .alpha.-1compounds

C - Chemistry, Metallurgy

07

K

530/7.1, 167/103

C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1246547

ABSTRACT OF THE DISCLOSURE Bis-thymosine .alpha.-1 consisting of two desacetylthymosine .alpha.-1 units N-terminally linked by a bridge bond of 1 to 10 carbon atoms, especially an .alpha.,.omega.-diacyl residue with 2 to 10 carbon atoms. This new compound is made by converting a synthetic desacetylthymosine .alpha.-1 in which all functional groups of amino acids 1 through 28, except the N-terminal group, are blocked by protective groups conventional in peptide synthesis with a coupling compound of 1 to 10 carbon atoms and that reacts with NH2 groups, in a polar solvent, and then removing the protective groups.

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