Bisacodyl dosage form

Details Bisacodyl dosage form Bisacodyl dosage form

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 9/14 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2156726

The subject invention involves pharmaceutical compositions in dosage unit form, for peroral administration of bisacodyl to a human or lower animal having a gastrointestinal tract, with a lumen threthrough, with a small intestine and a colon with a junction therebetween, comprising: (a) a safe and effective amount of rapidly-dissolving bisacodyl means; and (b) a delivery means which prevents the release of bisacodyl from the dosage form into the lumen of the gastrointestinal tract during transport of the dosage form through the lumen until the dosage form is near the junction between the small intestine and the colon or in the colon, and which then releases the bisacodyl in the lumen near the junction between the small intestine and the colon or within the colon. The subject invention also involves methods for providing laxation for humans and lower animals in need thereof by peroral administration of such compositions.

L'invention concerne des compositions pharmaceutiques, présentées sous forme galénique unitaire, destinées à l'administration perorale de bisacodyle chez l'homme ou l'animal doté d'un tractus gastro-intestinal comprenant un passage, d'un intestin grèle et d'un côlon reliés par une jonction. Ces compositions comprennent: (a) une dose efficace et sans danger d'une forme de bisacodyle à dissolution rapide; et (b) un dispositif de libération empêchant la libération du bisacodyle de la forme galénique dans le passage du tractus gastro-intestinal pendant le transport de cette forme galénique dans ledit passage jusqu'à ce qu'elle approche de la jonction entre l'intestin grèle et le côlon ou qu'elle pénètre dans le côlon, où le bisacodyle est libéré. L'invention concerne aussi des procédés qui permettent de produire une défécation chez l'homme ou l'animal la nécessitant, par administration pérorale de ces compositions.

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