Bisaryl derivatives having fsh receptor modulatory activity

Details Bisaryl derivatives having fsh receptor modulatory activity Bisaryl derivatives having fsh receptor modulatory activity

C - Chemistry, Metallurgy

07

D

C07D 241/08 (2006.01) A61K 31/4166 (2006.01) A61K 31/45 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61P 15/08 (2006.01) C07C 237/22 (2006.01) C07C 271/20 (2006.01) C07C 271/22 (2006.01) C07C 275/14 (2006.01) C07D 207/26 (2006.01) C07D 207/273 (2006.01) C07D 223/10 (2006.01) C07D 233/12 (2006.01) C07D 233/76 (2006.01) C07D 233/78 (2006.01) C07D 243/08 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2434184

The invention relates to a bisaryl derivative of the formula I, wherein (R, R) is selected from (H, H), O, (H, CH3), (H, OH) and (H, CN); Ar is substituted phenyl; and A is a group of following formula II, III, IV or V: The compounds of the invention have FSH receptor modulatory activity and can be used for the control of fertility, for contraception or for treatment of hormone-dependent disorders.

L'invention concerne un dérivé de bisaryle représenté par la formule (I), dans laquelle (R, R) est sélectionné dans (H, H), O, (H, CH¿3?), (H, OH) et (H, CN); Ar représente phényle substitué et A représente un groupe de formule (II), (III), (IV) ou (V). Ces composés possèdent une activité de modulation du récepteur de FSH et peuvent être utilisés dans les domaines du contrôle de la fertilité, de la contraception ou du traitement de maladies hormonales.

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