C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/60 (2006.01) A61K 31/44 (2006.01) A61K 31/4433 (2006.01) A61K 31/4439 (2006.01) A61K 31/4545 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) C07D 237/20 (2006.01) C07D 239/46 (2006.01)
Patent
CA 2576993
Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPARy or PPARS. In particular, the compounds of the invention modulate the function of PPARy or PPARS. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.
La présente invention a trait à des composés, des compositions et des procédés qui sont utiles dans le traitement ou la prévention d'une condition ou d'un trouble induit(e) par le PPAR.gamma. ou le PPAR.delta.. En particulier, les composés de l'invention modulent la fonction de PPAR.gamma. ou le PPAR.delta.. Les procédés de l'invention sont particulièrement utiles dans le traitement et/ou la prévention du diabète, de l'obésité, de l'hypercholestérolémie, de la polyarthrite rhumatoïde et de l'athérosclérose.
Bergeron Philippe
Farthing Christopher N.
Jones Stuart D.
Liebeschuetz John W.
Lively Sarah E.
Amgen Inc.
Smart & Biggar
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