Bisarylamines as potassium channel openers

Details Bisarylamines as potassium channel openers Bisarylamines as potassium channel openers

C - Chemistry, Metallurgy

07

D

C07D 498/02 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/445 (2006.01) A61K 31/505 (2006.01) A61P 25/00 (2006.01) A61P 25/08 (2006.01) C07D 211/68 (2006.01) C07D 239/02 (2006.01) C07D 401/00 (2006.01) C07D 401/12 (2006.01) C07D 413/00 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/00 (2006.01) C07D 471/02 (2006.01) C07D 497/02 (2006.01)

Patent

CA 2441565

Compounds of the following formula, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides bisarylamines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases) and as neuroprotective agents (e.g., to prevent stroke and the like) by opening potassium channels associated with the onset or recurrence of the indicated conditions. (see above formula)

L'invention concerne des composés, des compositions et des méthodes utilisées pour traiter des maladies par modulation d'un flux ionique de potassium dans des canaux potassium dépendant de la tension. L'invention concerne plus particulièrement des bisarylamines, des compositions et des méthodes utilisées pour traiter des troubles du système nerveux central ou périphérique (par exemple, la migraine, l'ataxie, la maladie de Parkinson, les troubles bipolaires, les névralgies faciales, la spasticité, les troubles de l'humeur, les tumeurs du cerveau, les troubles psychotiques, la myokymie, les crises, l'épilepsie, les pertes de la vision et de l'ouïe, la maladie d'Alzheimer, les pertes de mémoire associées à l'âge, les déficiences d'apprentissage, l'anxiété et les maladies neuromotrices), et comme agents neuroprotecteurs (par exemple, pour prévenir les accidents cérébrovasculaires et analogues) pour ouverture des canaux potassium associés à l'apparition ou à la récurrence des états précités.

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