C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/54 (2006.01) A61K 31/19 (2006.01) A61K 31/33 (2006.01) C07C 59/68 (2006.01) C07C 317/46 (2006.01) C07C 323/62 (2006.01) C07D 207/337 (2006.01) C07D 213/55 (2006.01) C07D 213/61 (2006.01) C07D 233/60 (2006.01) C07D 277/30 (2006.01) C07D 333/24 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2203412
Compounds having the formula (I): R1R2C(OR3)-Ar1-X-Ar2-C(Ar3)=CHCO2H are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
Les composés ayant la formule (I) R<1>R<2>C(OR<3>)-Ar<1>-X-Ar<2>-C(Ar<3>)=CHCO2H sont des inhibiteurs de la biosynthèse des leucotriènes. Ces composés sont utiles comme agents antiasthmatiques, antiallergiques, anti-inflammatoires et cytoprotecteurs. Ils sont également utiles pour traiter l'angine, les spasmes cérébraux, la néphrite glomérulaire, l'hépatite, l'endotoxémie, l'uvéite, les rejets d'allogreffes et pour empêcher la formation de plaques athéroscléreuses.
Delorme Daniel
Ducharme Yves
Friesen Richard
Grimm Erich
Lepine Carole
Goudreau Gage Dubuc
Merck Frosst Canada Inc.
Merck Frosst Canada Ltd.
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