Bisarylcarbinol derivatives as inhibitors of leukotriene...

Details Bisarylcarbinol derivatives as inhibitors of leukotriene... Bisarylcarbinol derivatives as inhibitors of leukotriene...

C - Chemistry, Metallurgy

07

D

C07D 311/16 (2006.01) A61K 31/37 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) C07D 405/04 (2006.01) C07D 407/04 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2203417

Compounds having the formula (I): R1R2C(OR3)-Ar1-X-Ar2-Ar3 are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.

L'invention se rapporte à des composés de la formule (I): R<1>R<2>C(OR<3>)-Ar<1>-X-Ar<2>-Ar<3>, qui sont des inhibiteurs de la biosynthèse des leucotriènes. Ces composés sont utiles comme agents anti-asthmatiques, anti-allergiques, anti-inflammatoires et cytoprotecteurs. Ils sont également utiles dans le traitement des angines, des spasmes cérébraux, des néphrites glomérulaires, de l'hépatite, de l'endotoxémie, de l'uvéite et des rejets d'allogreffes et dans la prévention de la formation de plaques athéroscléreuses.

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